abstract：:When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...

journal_title：PLoS biology

authors： Bays PM,Flanagan JR,Wolpert DM

更新日期：2006-02-01 00:00:00

abstract：:Pollination is exclusively or mainly animal mediated for 70% to 90% of angiosperm species. Thus, pollinators provide an essential ecosystem service to humankind. However, the impact of human-induced biodiversity loss on the functioning of plant-pollinator interactions has not been tested experimentally. To understand ...

journal_title：PLoS biology

authors： Fontaine C,Dajoz I,Meriguet J,Loreau M

更新日期：2006-01-01 00:00:00

abstract：:Previously it was shown that male mice, when they encounter female mice or their pheromones, emit ultrasonic vocalizations with frequencies ranging over 30-110 kHz. Here, we show that these vocalizations have the characteristics of song, consisting of several different syllable types, whose temporal sequencing include...

journal_title：PLoS biology

authors： Holy TE,Guo Z

更新日期：2005-12-01 00:00:00

abstract：:Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...

journal_title：PLoS biology

authors： Lacroix R,Mukabana WR,Gouagna LC,Koella JC

更新日期：2005-09-01 00:00:00

abstract：:The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep dep...

journal_title：PLoS biology

authors： Porrino LJ,Daunais JB,Rogers GA,Hampson RE,Deadwyler SA

更新日期：2005-09-01 00:00:00

abstract：:The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these conditions. Unequivocal proof of such an association, however, requires independent replication of initial positive finding...

journal_title：PLoS biology

authors： Swarbrick MM,Waldenmaier B,Pennacchio LA,Lind DL,Cavazos MM,Geller F,Merriman R,Ustaszewska A,Malloy M,Scherag A,Hsueh WC,Rief W,Mauvais-Jarvis F,Pullinger CR,Kane JP,Dent R,McPherson R,Kwok PY,Hinney A,Hebebrand J

更新日期：2005-09-01 00:00:00

abstract：:The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice ...

journal_title：PLoS biology

authors： Portera-Cailliau C,Weimer RM,De Paola V,Caroni P,Svoboda K

更新日期：2005-08-01 00:00:00

abstract：:With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena. The genetics of transcriptional regulation and protein abundance are likely to be complex, meaning that genetic variation at multiple loci will infl...

journal_title：PLoS biology

authors： Storey JD,Akey JM,Kruglyak L

更新日期：2005-08-01 00:00:00

abstract：:The illusion of apparent motion can be induced when visual stimuli are successively presented at different locations. It has been shown in previous studies that motion-sensitive regions in extrastriate cortex are relevant for the processing of apparent motion, but it is unclear whether primary visual cortex (V1) is al...

journal_title：PLoS biology

authors： Muckli L,Kohler A,Kriegeskorte N,Singer W

更新日期：2005-08-01 00:00:00

abstract：:Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and p...

journal_title：PLoS biology

authors： Nuismer SL,Otto SP

更新日期：2005-07-01 00:00:00

abstract：:Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

journal_title：PLoS biology

authors： Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

更新日期：2005-07-01 00:00:00

abstract：:microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to precursor miRNA (pre-m...

journal_title：PLoS biology

authors： Förstemann K,Tomari Y,Du T,Vagin VV,Denli AM,Bratu DP,Klattenhoff C,Theurkauf WE,Zamore PD

更新日期：2005-07-01 00:00:00

abstract：:We used a class of designed peptide detergents to stabilize photosystem I (PS-I) upon extended drying under N2 on a gold-coated-Ni-NTA glass surface. PS-I is a chlorophyll-containing membrane protein complex that is the primary reducer of ferredoxin and the electron acceptor of plastocyanin. We isolated the complex fr...

journal_title：PLoS biology

authors： Kiley P,Zhao X,Vaughn M,Baldo MA,Bruce BD,Zhang S

更新日期：2005-07-01 00:00:00

abstract：:Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors. The yeast protein Trf4p has been implicated in a quality control pathway that leads to the polyadenylation and subsequent exosome-...

journal_title：PLoS biology

authors： Vanácová S,Wolf J,Martin G,Blank D,Dettwiler S,Friedlein A,Langen H,Keith G,Keller W

更新日期：2005-06-01 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:Why do we sleep? The sleep patterns and mechanisms that occur throughout development may give us a clue. ...

journal_title：PLoS biology

authors： Siegel JM

更新日期：2005-05-01 00:00:00

abstract：:One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of the large phenotypic variability seen in nature. Here, we use an unsupervised, systematic approach for associating genes a...

journal_title：PLoS biology

authors： Korbel JO,Doerks T,Jensen LJ,Perez-Iratxeta C,Kaczanowski S,Hooper SD,Andrade MA,Bork P

更新日期：2005-05-01 00:00:00

abstract：:The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phen...

journal_title：PLoS biology

authors： Leone TC,Lehman JJ,Finck BN,Schaeffer PJ,Wende AR,Boudina S,Courtois M,Wozniak DF,Sambandam N,Bernal-Mizrachi C,Chen Z,Holloszy JO,Medeiros DM,Schmidt RE,Saffitz JE,Abel ED,Semenkovich CF,Kelly DP

更新日期：2005-04-01 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP hydrolysis. When filaments form on duplex DNA, RecA protein exhibits a fu...

journal_title：PLoS biology

authors： Cox JM,Tsodikov OV,Cox MM

更新日期：2005-02-01 00:00:00

abstract：:Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...

journal_title：PLoS biology

authors： Pejchal R,Ludwig ML

更新日期：2005-02-01 00:00:00

abstract：:The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regions of the longest ...

journal_title：PLoS biology

authors： Sherwood NT,Sun Q,Xue M,Zhang B,Zinn K

更新日期：2004-12-01 00:00:00

abstract：:The rapid destruction of the planet's biodiversity has prompted the nations of the world to set a target of achieving a significant reduction in the rate of loss of biodiversity by 2010. However, we do not yet have an adequate way of monitoring progress towards achieving this target. Here we present a method for produ...

journal_title：PLoS biology

authors： Butchart SH,Stattersfield AJ,Bennun LA,Shutes SM,Akçakaya HR,Baillie JE,Stuart SN,Hilton-Taylor C,Mace GM

更新日期：2004-12-01 00:00:00

abstract：:Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

journal_title：PLoS biology

authors： Denk W,Horstmann H

更新日期：2004-11-01 00:00:00

abstract：:In nature, Escherichia coli are exposed to harsh and non-ideal growth environments-nutrients may be limiting, and cells are often challenged by oxidative stress. For E. coli cells confronting these realities, there appears to be a link between oxidative stress, methionine availability, and the enzyme that catalyzes th...

journal_title：PLoS biology

authors： Hondorp ER,Matthews RG

更新日期：2004-11-01 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00

abstract：:The segmentation gene network of Drosophila consists of maternal and zygotic factors that generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity along the anterior-posterior axis of the embryo. Using known binding site information for maternal and zygotic gap transcription facto...

journal_title：PLoS biology

authors： Schroeder MD,Pearce M,Fak J,Fan H,Unnerstall U,Emberly E,Rajewsky N,Siggia ED,Gaul U

更新日期：2004-09-01 00:00:00

abstract：:The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. H...

journal_title：PLoS biology

authors： Schnatwinkel C,Christoforidis S,Lindsay MR,Uttenweiler-Joseph S,Wilm M,Parton RG,Zerial M

更新日期：2004-09-01 00:00:00

abstract：:Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated wit...

journal_title：PLoS biology

authors： Kaeberlein M,Kirkland KT,Fields S,Kennedy BK

更新日期：2004-09-01 00:00:00

abstract：:The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...

journal_title：PLoS biology

authors： Foley E,O'Farrell PH

更新日期：2004-08-01 00:00:00

abstract：:Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus. In yeast, a large set of UPR target genes has been experimentally determined, but the previo...

journal_title：PLoS biology

authors： Patil CK,Li H,Walter P

更新日期：2004-08-01 00:00:00

abstract：:Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...

journal_title：PLoS biology

authors： Fortna A,Kim Y,MacLaren E,Marshall K,Hahn G,Meltesen L,Brenton M,Hink R,Burgers S,Hernandez-Boussard T,Karimpour-Fard A,Glueck D,McGavran L,Berry R,Pollack J,Sikela JM

更新日期：2004-07-01 00:00:00

abstract：:CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated from injured Pax7( ...

journal_title：PLoS biology

authors： Seale P,Ishibashi J,Scimè A,Rudnicki MA

更新日期：2004-05-01 00:00:00

abstract：:A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the...

journal_title：PLoS biology

authors： Landgraf C,Panni S,Montecchi-Palazzi L,Castagnoli L,Schneider-Mergener J,Volkmer-Engert R,Cesareni G

更新日期：2004-01-01 00:00:00

abstract：:The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

journal_title：PLoS biology

authors： Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

更新日期：2003-12-01 00:00:00

abstract：:Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...

journal_title：PLoS biology

authors： Hipfner DR,Cohen SM

更新日期：2003-11-01 00:00:00

abstract：:RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to th...

journal_title：PLoS biology

authors： Simmer F,Moorman C,van der Linden AM,Kuijk E,van den Berghe PV,Kamath RS,Fraser AG,Ahringer J,Plasterk RH

更新日期：2003-10-01 00:00:00